MAO-IN-M30 dihydrochloride

Research use only, not for human use.

Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively).

Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.(In Vitro):MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.(In Vivo):MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.

M 30 dihydrochloride

Others

Other Targets

——

——

——

64821-19-8

299.2

C14H14N2O.2HCl

>98% (HPLC)

——

CN(CC#C)CC1=C2C(N=CC=C2)=C(O)C=C1.Cl.Cl

——

(-20℃)

With Ice Pack

≥ 2 years